Drug Pelleting (Multiparticulate Systems)

Benefits of ES Drug Pelleting

• Achieve maximum drug loading of your API
• Create smaller spheres with higher drug loading than the typical limitations of spheres produced by drug layering
• Easily combine incompatible active ingredients (multiparticulate systems)
• Create a pellets for a more patient friendly dosage form for Geriatric and Pediatric populations or for those who would otherwise have difficulty swallowing a pill
• Create controlled release pellets with narrow particle size distribution resulting in highly controlled release profiles
• Develop a pelletization process with excellent process repeatability
• Scale up from the laboratory to production easily
• Increase yield of high value products
• Tamper proof products with the use of matrix pellets
• Limit side effects with pellets that disperse and do not dose dump locally as with tablets
• Achieve faster processing of large quantities as compared with spheres produced by drug layering
• Allow for extended patent life with a more complex drug delivery system

Final Dosage Examples using ES Drug Pellets

Pharmaceutical Case Studies

Continuous Extrusion-Spheronization