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Dome Ex Kneader-Extruder Continuous Wet Granulation
DOME-EX System
The DOME-EX System provides continuous wet granulation/pelleting of pharmaceutical powder blends for subsequent tableting.
The unique features of the DOME-EX allow it to continuously produce micro-granules of uniform diameter and hardness. This continuous processing concept eliminates the need for slow, batch granulation (e.g. high shear, and fluid bed granulators), and yields a streamlined, high capacity, more consistent (minimal variability) process.
The DOME-EX System:
- Dry mixes
- Feeds (meters)
- Wet mixes (kneader)
- Extrudes
- Dries continuously
Pre-blended powders are continuously metered into the DOME-EX using a powder feeder (sold separately). Liquid is added using a peristaltic pump. The DOME-EX twin screws intimately knead/mix the material and transport it continuously into the inlet of the vertical extruder equipped with a dome die. The wet mass is gently wiped though the dome die producing fine, dense, cylindrical granules of a specific diameter. The prepared wet material is manually fed.
![Particles produced by Dome-EX Kneader Mixer Extruder](https://edge.sitecorecloud.io/nedermanhol8b6a-nederman990f-productioneb8a-83b9/media/Project/Nederman/LCI/Products/Continuous-Wet-Granulation/Domex-particles1.jpg)
Features & Benefits
- Pre-compaction before tableting
- Uniform size (as compared to mixer/granulator)
- 10-25 kg/hr extrusion rate
- Twin screw kneader-extruder
- Integrated vertical extrusion system (Dome type)
- Separate powder and liquid inlet ports
- Dome dies available with 0.2 and 0.3 mm hole diameter
- GMP design with 316SS product contact parts
- Quick clamps for dome die removal, liquid inlet port
- Systems designed for easy assembly, disassembly, and cleaning
- Control panel with PLC/HMI to operate the DOME-EX
- Touch-screen color HMI; Start/Stop/Speed Control
- Displays motor torque, RPM, Alarms
**Powder feeder and liquid pump sold separately
![Dome-EX Kneader Mixer Extruder](https://edge.sitecorecloud.io/nedermanhol8b6a-nederman990f-productioneb8a-83b9/media/Project/Nederman/LCI/Products/Continuous-Wet-Granulation/Domex-image.jpg)